Chronic pain: How memory and emotions influence its persistence, health experts say

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By: Daniel Harris

Pain is not just a biological alarm signal alerting us to harm; it can etch deep marks on both mind and body, lingering long after its initial cause has vanished. This phenomenon, where memory and emotion play crucial roles, affects millions globally and becomes especially relevant as we approach World Pain Day. Dr. Jordi Serra, who leads the Pain Treatment Unit at the Hospital Universitari Dexeus in Barcelona, shared insights with EFE Salud, explaining that pain initiation involves intense stimulation of nerve endings, which then transmit signals to the brain. This process is not purely physical; it also activates emotional mechanisms, leading to responses such as fear and anxiety.

The Complexity of Pain Perception

Pain is a highly subjective experience, varying significantly among individuals and even within an individual over time. Dr. Serra emphasizes that this variability stems from a complex interplay of biological, emotional, social, and cultural factors. The intensity and expression of pain can be influenced by one’s emotional environment, personal history, and social circumstances.

Memory and Emotion: Drivers of Persistent Pain

Memory and emotions are pivotal in the persistence of pain. From the onset, the brain records pain, a mechanism once crucial for survival. However, in cases of chronic pain resistant to treatment, this ‘pain memory’ keeps the discomfort active due to the brain’s neuroplastic abilities. This adaptability allows the brain to reinterpret non-painful stimuli as pain.

The emotional and psychological state of a person also modulates pain perception. Dr. Serra points out that the term “psychogenic pain” has been phased out from international classifications, reflecting a more nuanced understanding of the mind-body interaction.

Unique Cases and Complex Phenomena

Pain’s complexity is highlighted in exceptional cases such as congenital analgesia, where individuals, due to a non-functioning nociceptive system, do not experience pain, leading to risks like burns or injuries from unperceived threats. Another intriguing phenomenon is phantom limb syndrome, where pain is felt in a limb that is no longer present, maintained by abnormal peripheral activity, spinal sensitization, and cortical reorganization.

Challenges in Pain Measurement

Assessing pain remains a formidable challenge in medicine. Although there are tools designed with algorithms that consider physiological parameters, their clinical use is limited. The primary method for evaluating pain in medical settings remains the subjective reports from patients, using numerical or visual scales tailored to age and cognitive capabilities. In scenarios where communication is impossible, observational scales are utilized.

For chronic pain, multidimensional and functional interference scales are employed, alongside disease-specific tools for conditions like hand arthritis or hip osteoarthritis. In complex chronic pain cases, memory and neuroplasticity can transform harmless stimuli into painful sensations, showcasing the brain’s capacity to reconfigure pain perception and presenting additional challenges in pain management, concludes Dr. Serra.


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