5 Week 1 NFL Injuries To Watch In 2025, And Who’s On Thin Ice

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By: Jessica Morrison

Shock hit early: five surprising Week 1 injuries are already forcing teams to adapt and fantasy managers to panic. These notes – compiled by SI’s injury updates and team reports – arrive with a concrete change: one top tight end has been placed on IR. We tease the biggest surprise (a starter sidelined for multiple weeks) and explain why you should change waivers now. Which starters do you drop or stash before Sunday?

Which Five Week 1 Injuries Demand Immediate Roster Moves?

  • George Kittle placed on IR after a Week 1 hamstring; 49ers will be without his snaps.
  • Brock Bowers left with a knee hit but is expected to play on Sep. 15.
  • Xavier Worthy suffered a dislocated shoulder and awaits further testing.
  • Drake London left with a shoulder sprain and is listed day‑to‑day.
  • Jauan Jennings exited with a shoulder injury; MRI pending for exact timeline.

The Top 5 Picks From Week 1 That Will Shape Lineups This Week

1 – George Kittle’s IR Placement: Why One Tight End Loss Upsets Dozens Of Lineups

George Kittle left Week 1 with a hamstring issue and was placed on IR, per team and local coverage. That single roster move removes a top TE target and forces 49ers gameplans to redirect looks – fantasy owners, expect TE streaming conversations and abrupt waiver urgency.

2 – Brock Bowers’ Knee Scare, But Return Looms On Sep. 15 – Can You Trust Him?

Brock Bowers was forced out late with a knee hit, though reports say no major setback and he’s expected to suit up on Sep. 15. His volume (team-high receiving yards before exit) keeps him a starter when active, but managers may want an insurance bench piece for Week 2.

3 – Xavier Worthy’s Dislocated Shoulder: Rookie Status Suddenly Fragile

Chiefs rookie Xavier Worthy left after colliding with a teammate; testing revealed a dislocated shoulder, according to Ian Rapoport and SI coverage. That’s a physical, recovery-driven injury – if he misses time, Chiefs WR depth rotations will open, and fantasy sleepers could emerge.

4 – Drake London Day‑To‑Day After Shoulder Sprain – Short Downtime Or Red Flag?

Drake London exited with a shoulder sprain and is listed as day‑to‑day after Week 1, per SI updates. For fantasy players: monitor practice reports; a missed game could knock him out of startable range for conservative rosters.

5 – Jauan Jennings’ Shoulder, MRI Incoming – Lowered Ceiling Until Clearance

Jennings left the opener with a shoulder injury and is set for an MRI to define recovery time. Until results arrive, his target share is uncertain – bench him if you need reliability, or stash a backup with immediate upside.

How These 5 Injuries Turn Week 2 Matchups Into Roster Chaos – Key Numbers To Track

KPI Value + Unit Change/Impact
Notable Week 1 Injuries 5 players Multiple starters affected across teams
Players Placed On IR 1 player George Kittle out, forcing TE adjustments
Day‑To‑Day Key WRs 1 player Drake London listed day‑to‑day for Week 2

Week 2 fantasy lineups must adapt quickly as injuries redefine target distribution.

What To Do Now: 3 Quick Moves Every Manager Should Make Before Week 2

Act fast: (1) Chase a streaming TE or claim a Bowers insurance bench if your league depth is thin, (2) monitor Chiefs practice reports for Worthy and add a handcuff WR if needed, (3) stash or pick up immediate target replacements in shallow leagues. Want a meme-ready waiver move to ignite your league chat – who will you gamble on this week?

Sources

  • https://www.si.com/onsi/fantasy/injuries/brock-bowers-and-4-other-nfl-week-1-injury-updates
  • https://www.si.com/nfl/jaguars/jacksonville-george-kittle-liam-coen-san-francisco-49ers-kyle-shanahan
  • https://www.si.com/nfl/falcons/news/falcons-release-wednesday-week-1-injury-report-01k494xtmajt

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